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Finally, perturbations in TSC, a shared component of the growth factor and AA sensing machineries, were shown to modulate aging in model organisms: flies overexpressing dTSC1 and dTSC2 live longer, due to decreased TORC1 activity (Kapahi et al., 2004)

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doi: 10.1016/j.micpath.2014.06.002 [DOI] [PubMed] [Google Scholar] [32].O’Callaghan D, Cazevieille C, Allardet‐Servent A, et al